Print Email Facebook Twitter Laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy Title Laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy: a systematic review and meta-analysis Author Sandberg, E.M. (Leiden University Medical Center) la Chapelle, C.F. (Leiden University Medical Center) van den Tweel, M. (Leiden University Medical Center) Schoones, J.W. (Leiden University Medical Center) Jansen, F.W. (TU Delft Medical Instruments & Bio-Inspired Technology; Leiden University Medical Center) Date 2017 Abstract Purpose: To assess the safety and effectiveness of LESS compared to conventional hysterectomy. Methods: The systematic review and meta-analysis was performed according to the MOOSE guideline, and quality of evidence was assessed using GRADE. Different databases were searched up to 4th of August 2016. Randomized controlled trials and cohort studies comparing LESS to the conventional laparoscopic hysterectomy were considered for inclusion. Results: Of the 668 unique articles, 23 were found relevant. We investigated safety by analyzing the complication rate and found no significant differences between both groups [OR 0.94 (0.61, 1.44), I2 = 19%]. We assessed effectiveness by analyzing conversion risk, postoperative pain, and patient satisfaction. For conversion rates to laparotomy, no differences were identified [OR 1.60 (0.40, 6.38), I2 = 45%]. In 3.5% of the cases in the LESS group, an additional port was needed during LESS. For postoperative pain scores and patient satisfaction, some of the included studies reported favorable results for LESS, but the clinical relevance was non-significant. Concerning secondary outcomes, only a difference in operative time was found in favor of the conventional group [MD 11.3 min (5.45–17.17), I2 = 89%]. The quality of evidence for our primary outcomes was low or very low due to the study designs and lack of power for the specified outcomes. Therefore, caution is urged when interpreting the results. Conclusion: The single-port technique for benign hysterectomy is feasible, safe, and equally effective compared to the conventional technique. No clinically relevant advantages were identified, and as no data on cost effectiveness are available, there are currently not enough valid arguments to broadly implement LESS for hysterectomy. Subject Conventional laparoscopyHysterectomyLESSSingle-port surgery To reference this document use: http://resolver.tudelft.nl/uuid:03633969-ee68-4c83-a599-cd6527af7b95 DOI https://doi.org/10.1007/s00404-017-4323-y ISSN 0932-0067 Source Archives of Gynecology and Obstetrics, 295 (5), 1089-1103 Part of collection Institutional Repository Document type journal article Rights © 2017 E.M. Sandberg, C.F. la Chapelle, M. van den Tweel, J.W. Schoones, F.W. Jansen Files PDF art_10.1007_s00404_017_4323_y.pdf 2.85 MB Close viewer /islandora/object/uuid:03633969-ee68-4c83-a599-cd6527af7b95/datastream/OBJ/view