Print Email Facebook Twitter Tandem reactions in self-sorted catalytic molecular hydrogels Title Tandem reactions in self-sorted catalytic molecular hydrogels Author Singh, N. (Universitat Jaume I) Zhang, K. (TU Delft ChemE/Advanced Soft Matter) Angulo-Pachón, C.A. (Universitat Jaume I) Mendez Sevillano, D. (TU Delft BT/Bioprocess Engineering) van Esch, J.H. (TU Delft ChemE/Advanced Soft Matter) Escuder, B. (Universitat Jaume I) Date 2016-05-09 Abstract By equipping mutually incompatible carboxylic acid and proline catalytic groups with different self-assembling motives we have achieved self-sorting of the resulting catalytic gelators, namely SucVal8 and ProValDoc, into different supramolecular fibers, thus preventing the acidic and basic catalytic groups from interfering with each other. The resulting spatial separation of the incompatible catalytic functions is found to be essential to achieve one-pot deacetalization–aldol tandem reactions with up to 85% efficiency and 90% enantioselectivity. On the contrary, when SucVal8 was co-assembled with a structurally similar catalytically active hydrogelator (ProVal8), self-sorting was precluded and no tandem catalysis was observed. To reference this document use: http://resolver.tudelft.nl/uuid:05342ba9-5fb4-47cb-bf71-9329747106ab DOI https://doi.org/10.1039/C6SC01268J ISSN 2041-6520 Source Chemical Science, 5568-5572 Part of collection Institutional Repository Document type journal article Rights © 2016 N. Singh, K. Zhang, C.A. Angulo-Pachón, D. Mendez Sevillano, J.H. van Esch, B. Escuder Files PDF c6sc01268j.pdf 603.66 KB Close viewer /islandora/object/uuid:05342ba9-5fb4-47cb-bf71-9329747106ab/datastream/OBJ/view