Print Email Facebook Twitter Incidence and groups at risk for unexpected uterine leiomyosarcoma Title Incidence and groups at risk for unexpected uterine leiomyosarcoma: a Dutch nationwide cohort study Author van den Haak, Lukas (Leiden University Medical Center) de Kroon, Cor D. (Leiden University Medical Center) Warmerdam, Milo I. (Leiden University Medical Center) Siebers, Albert G. (Nationwide Network and Registry of Histo- and Cytopathology in The Netherlands) Rhemrev, Johann P. (Haaglanden Medical Center) Nieboer, Theodoor E. (Radboud Universiteit Nijmegen) Jansen, F.W. (TU Delft Medical Instruments & Bio-Inspired Technology; Leiden University Medical Center) Date 2019 Abstract Objective: To estimate the risk of uterine leiomyosarcoma in patients undergoing gynecological surgery and also to identify groups at risk for unrecognized uterine leiomyosarcoma. Methods: A national cohort study was performed evaluating all uterine leiomyosarcoma (ULMS) diagnosed in The Netherlands between January 2000 and September 2015. Cases were identified and supplied by the nationwide network and registry of histo- and cytopathology in The Netherlands (PALGA). Unexpected and expected ULMS were compared. Approval for this study was granted by the Medical Ethics Committee of all participating hospitals and by the review board of PALGA. Results: 262 original cases were included. The overall incidence of ULMS in our study was 0.25% or 1:400 patients. The incidence of unexpected ULMS was 0.12% or 1:865 patients. Preoperatively, a malignancy was unexpected in 46% of the cases and expected in 54%. Abnormal uterine bleeding constituted most of the symptoms. 90% of women underwent abdominal hysterectomy and/or bilateral salpingo-oophorectomy. Conclusions: Leiomyosarcoma are rare. Women aged 40–50 years with abnormal uterine bleeding are most at risk for unexpected ULMS. In contrast, this risk is low in postmenopausal women. ULMS were highly uncommon in women aged under 40 years. Subject HysterectomyLaparoscopyLeiomyosarcomaMorcellation To reference this document use: http://resolver.tudelft.nl/uuid:12a9aa52-dc21-48e8-9e3a-04bbdbb26483 DOI https://doi.org/10.1007/s00404-018-4949-4 ISSN 0932-0067 Source Archives of Gynecology and Obstetrics, 299 (1), 159-165 Part of collection Institutional Repository Document type journal article Rights © 2019 Lukas van den Haak, Cor D. de Kroon, Milo I. Warmerdam, Albert G. Siebers, Johann P. Rhemrev, Theodoor E. Nieboer, F.W. Jansen Files PDF Haak2018_Article_Incidenc ... ForUne.pdf 723.34 KB Close viewer /islandora/object/uuid:12a9aa52-dc21-48e8-9e3a-04bbdbb26483/datastream/OBJ/view