Print Email Facebook Twitter What makes long DNA short? Title What makes long DNA short?: Modulation of DNA structure by Dps protein: cooperating & reorganizing Author Vtyurina, N. (TU Delft BN/Elio Abbondanzieri Lab) Contributor Dekker, N.H. (promotor) Abbondanzieri, E. (copromotor) Degree granting institution Delft University of Technology Date 2016-09-09 Abstract Each confined cell created by nature and containing DNA molecule falls into the category of “alive organism”. All information about this organism is encoded in DNA molecule in genes, except of fate only. Along with the DNA molecule that represents genetic carrier, the organism neither the genome could function without proteins. Proteins are the building blocks from which cells are assembled and capable of activating or disabling particular genes playing a crucial role in DNA replication, repair and protection. In order to understand the function of each singular protein and its role in the overall cellular metabolism, we need to characterize it from different perspectives. Without this knowledge, we do not possess a complete picture of the vitally important processes in the cell and might be losing a very promising pipeline for a treatment of many diseases. Subject single-moleculeDNA condensationDps proteincooperativityreorganizationhysteresisIsing model To reference this document use: https://doi.org/10.4233/uuid:14080918-3a6e-48ad-8c47-906538f689ac ISBN 978-90-8593-262-8 Embargo date 2017-01-01 Part of collection Institutional Repository Document type doctoral thesis Rights © 2016 N. Vtyurina Files PDF PhD_thesis_Natalia_Vtyurina.pdf 7.85 MB Close viewer /islandora/object/uuid:14080918-3a6e-48ad-8c47-906538f689ac/datastream/OBJ/view