Print Email Facebook Twitter Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI Title Brain Dynamic Information Flow Estimation Based on EEG and Diffusion MRI: A Proof-of-principle Study and Application in Stroke Author Tian, Runfeng (TU Delft Mechanical, Maritime and Materials Engineering) Contributor van der Helm, Frans (mentor) Yang, Yuan (mentor) Filatova, Lena (mentor) Pool, Daan (graduation committee) Degree granting institution Delft University of Technology Programme Mechanical Engineering Date 2018-08-30 Abstract In the hemiparetic stroke, functional recovery of paretic limb may occur with the reorganization of neural networks in the brain. Electroencephalography (EEG), with an excellent temporal resolution, can be used to reveal functional changes in the brain following a stroke. This study assessed a novel multimodal brain imaging technique namely Variational Bayesian Multimodal Encephalography (VBMEG), which combines EEG, anatomical MRI and diffusion weighted imaging (DWI), to estimation brain dynamic information flow and its changes following a stroke. EEG data were acquired from individuals suffering from a stroke as well as able-bodied participants while electrical stimuli were delivered sequentially at their index finger in the left and right hand, respectively. The locations of active sources related to this stimulus were precisely identified, resulting in high Variance Accounted For (VAF above 80%). An accurate estimation of dynamic information flow between sources was achieved in this study, showing a high VAF (above 88%) in the cross-validation test. The estimated dynamic information flow was compared between chronic hemiparetic stroke and able-bodied individuals, using matrices lateralization index and activation complexity. The results demonstrate the feasibility of VBMEG method in revealing the changes of information flow in the brain after stroke. This study verified the VBMEG method as an advanced computational approach to track the dynamic information flow in the brain following a stroke. This may lead to the development of a quantitative tool for monitoring functional changes of the cortical neural networks after a unilateral brain injury and therefore facilitate the research into, and the practice of stroke rehabilitation. Subject EEGdiffusion MRIdynamic information flowVBMEG To reference this document use: http://resolver.tudelft.nl/uuid:1a44d771-6187-4259-9123-de10c5740e52 Embargo date 2020-08-30 Part of collection Student theses Document type master thesis Rights © 2018 Runfeng Tian Files PDF Thesis_Runfeng.pdf 2.71 MB Close viewer /islandora/object/uuid:1a44d771-6187-4259-9123-de10c5740e52/datastream/OBJ/view