Print Email Facebook Twitter Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects Title Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects Author Bhardwaj, R. (TU Delft RST/Applied Radiation & Isotopes) van der Meer, A.J.G.M. (TU Delft RST/Applied Radiation & Isotopes) Das, S.K. (TU Delft RST/Applied Radiation & Isotopes) de Bruin, M (TU Delft RST/Radiation, Science and Technology) Gascon, Jorge (TU Delft ChemE/Catalysis Engineering) Wolterbeek, H.T. (TU Delft RST/Radiation, Science and Technology) Denkova, A.G. (TU Delft RST/Applied Radiation & Isotopes) Serra Crespo, P. (TU Delft RST/Applied Radiation & Isotopes) Department RST/Radiation, Science and Technology Date 2017-03-13 Abstract 177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a separation method that achieves the challenging separation of the physically and chemically identical nuclear isomers, 177mLu and 177Lu. The separation method combines the nuclear after-effects of the nuclear decay, the use of a very stable chemical complex and a chromatographic separation. Based on this separation concept, a new type of radionuclide generator has been devised, in which the parent and the daughter radionuclides are the same elements. The 177mLu/177Lu radionuclide generator provides a new production route for the therapeutic radionuclide 177Lu and can bring significant growth in the research and development of 177Lu based pharmaceuticals. Subject Medicinal chemistryNuclear chemistryOA-Fund TU Delft To reference this document use: http://resolver.tudelft.nl/uuid:2203c36d-6747-4263-aec1-db958c3647de DOI https://doi.org/10.1038/srep44242 ISSN 2045-2322 Source Scientific Reports, 7 Part of collection Institutional Repository Document type journal article Rights © 2017 R. Bhardwaj, A.J.G.M. van der Meer, S.K. Das, M de Bruin, Jorge Gascon, H.T. Wolterbeek, A.G. Denkova, P. Serra Crespo Files PDF srep44242.pdf 1.2 MB Close viewer /islandora/object/uuid:2203c36d-6747-4263-aec1-db958c3647de/datastream/OBJ/view