Bootstrapping in the Cox-model with interval censored observations

Bootstrapping in the Cox-model with interval censored observations

Gouwens, Sigur (TU Delft Electrical Engineering, Mathematics and Computer Science)

Jongbloed, Geurt (mentor)

Delft University of Technology

Applied Mathematics

2019-12-01

In this study the interval censoring case 2 model combined with the Cox model is considered. The event-time distribution function is modeled nonparametrically. Two algorithms are proposed to estimate the event-time distribution function together with the Cox coefficients. Kernel smoothing is applied to the non-parametric MLE of the event-time distribution resulting in the smoothed MLE (SMLE). A two-step method for choosing the smoothing bandwidth based on minimising the MSE is introduced. Given the SMLE, the precision of the MLE is tested using bootstrap simulations. New event-times are sampled from the SMLE which are then used to compute bootstrap estimates of the event-time distribution. This is done for multiple sample sizes to observe large sample behaviour. This study suggests that larger sample sizes lead to
better estimates. Monte Carlo simulations and the bootstrap simulations agree on the bandwidth and the large sample distribution of pointwise estimates of the event-time distribution.

Survival analysis
Cox model
Interval Censoring
Bootstrap

http://resolver.tudelft.nl/uuid:2e7bbcb9-b83a-43fa-8c5f-b1f684b48ac7

Student theses

master thesis

© 2019 Sigur Gouwens