Photoacoustic imaging of human coronary atherosclerosis in two spectral bands

Title

Photoacoustic imaging of human coronary atherosclerosis in two spectral bands

 Author

Jansen, K.
Wu, M.
Van der Steen, A.F.W.
Van Soest, G.

Faculty

Applied Sciences

 Department

ImPhys/Imaging Physics

 Date

2014-03-01

 Abstract

Spectroscopic intravascular photoacoustic imaging (sIVPA) has shown promise to detect and distinguish lipids in atherosclerotic plaques. sIVPA generally utilizes one of the two high absorption bands in the lipid absorption spectrum at 1.2 ?m and 1.7 ?m. Specific absorption signatures of various lipid compounds within the bands in either wavelength range can potentially be used to differentiate between plaque lipids and peri-adventitial lipids. With the aim to quantify any differences between the two bands, we performed combined sIVPA imaging in both absorption bands on a vessel phantom and an atherosclerotic human coronary artery ex vivo. Lipid detection in a human atherosclerotic lesion with sIVPA required lower pulse energy at 1.7 ?m than at 1.2 ?m (0.4 mJ versus 1.2 mJ). The imaging depth was twice as large at 1.2 ?m compared to 1.7 ?m. Adequate differentiation between plaque and peri-adventitial lipids was achieved at 1.2 ?m only.

 Subject

intravascular imaging
atherosclerosis
vulnerable plaque
tissue characterization
spectroscopy
lipids

 To reference this document use:

http://resolver.tudelft.nl/uuid:368a58f7-4b6a-48a4-b8e7-f3b9d5b8a20c

 DOI

https://doi.org/10.1016/j.pacs.2013.11.003

 Publisher

Elsevier

 ISSN

2213-5979

 Source

Photoacoustics, 2 (1), 2014

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

(c) 2014 The Author(s)
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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