Print Email Facebook Twitter Polyphenol Liquid-Liquid Extraction Process Development Using NRTL-SAC Title Polyphenol Liquid-Liquid Extraction Process Development Using NRTL-SAC Author Henriques da Silva, M.D. (TU Delft BT/Bioprocess Engineering) Cortada García, J. (TU Delft Applied Sciences) Ottens, M. (TU Delft BT/Bioprocess Engineering) Faculty Applied Sciences Date 2018-07-18 Abstract Liquid-liquid extraction (LLE) can be an effective strategy for the purification of polyphenols from a fermentation broth. However, solvents need to be chosen to ensure high extraction capacity and selectivity. For that purpose, a systematic study is here presented, where the partition of different polyphenols - naringin, naringenin, p-coumaric acid, and trans-resveratrol - was measured in different solvents and solvent mixtures and described using the semipredictive NRTL-SAC model. The minimum average absolute deviation obtained, based on predicted activity coefficients, was of 40%. With the exception of naringin, the NRTL-SAC molecular descriptors were estimated using solubility data already available in the literature. The obtained results made it possible to propose suitable LLE-based downstream process schemes for two possible purification scenarios: the recovery of trans-resveratrol and the purification of both naringenin and trans-resveratrol, two similar hydrophobic polyphenols, both from a fermentation broth containing hydrophilic impurities (e.g., sugars, proteins). To reference this document use: http://resolver.tudelft.nl/uuid:3dece4c1-f6a5-4367-bd8a-75c500c6e422 DOI https://doi.org/10.1021/acs.iecr.8b00613 ISSN 0888-5885 Source Industrial and Engineering Chemistry Research, 57 (28), 9210-9221 Part of collection Institutional Repository Document type journal article Rights © 2018 M.D. Henriques da Silva, J. Cortada García, M. Ottens Files PDF acs.iecr.8b00613.pdf 4.41 MB Close viewer /islandora/object/uuid:3dece4c1-f6a5-4367-bd8a-75c500c6e422/datastream/OBJ/view