Print Email Facebook Twitter The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment Title The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment Author Papma, Janne M. (Erasmus MC) Smits, Marion (Erasmus MC) De Groot, Marius (Erasmus MC) Mattace-Raso, Francesco U. S. (Erasmus MC) van der Lugt, Aad (Erasmus MC) Vrooman, Henri A. (Erasmus MC) Niessen, W.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC) Koudstaal, Peter J. (Erasmus MC) van Swieten, John C. (Erasmus MC) van der Veen, Frederik M. (Erasmus Universiteit Rotterdam) Prins, Niels D. (Amsterdam UMC) Date 2017-09-01 Abstract Objectives: Diminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer’s disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI). Method: MCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging. Stepwise linear regression analysis was performed to examine the relationship between PCC activation and hippocampal activation, hippocampal volume and diffusion measures within the cingulum along the hippocampus. Results: We found a significant relationship between PCC and hippocampus activation during successful episodic memory encoding and correct recognition in MCI patients. We found no relationship between the PCC and structural hippocampal predictors. Conclusions: Our results indicate a relationship between PCC and hippocampus activation during episodic memory engagement in MCI. This may suggest that during episodic memory, functional network deterioration is the most important predictor of PCC functioning in MCI. Key Points: • PCC functioning during episodic memory relates to hippocampal functioning in MCI. • PCC functioning during episodic memory does not relate to hippocampal structure in MCI. • Functional network changes are an important predictor of PCC functioning in MCI. Subject Diffusion tensor imagingEpisodic memory task-related functional MRIHippocampusMild cognitive impairmentPosterior cingulate cortex To reference this document use: http://resolver.tudelft.nl/uuid:4e265b8b-1110-40d1-9e78-4f793e03a00e DOI https://doi.org/10.1007/s00330-017-4768-1 ISSN 0938-7994 Source European Radiology, 27 (9), 3716-3724 Part of collection Institutional Repository Document type journal article Rights © 2017 Janne M. Papma, Marion Smits, Marius De Groot, Francesco U. S. Mattace-Raso, Aad van der Lugt, Henri A. Vrooman, W.J. Niessen, Peter J. Koudstaal, John C. van Swieten, Frederik M. van der Veen, Niels D. Prins Files PDF 10.1007_s00330_017_4768_1.pdf 1.99 MB Close viewer /islandora/object/uuid:4e265b8b-1110-40d1-9e78-4f793e03a00e/datastream/OBJ/view