Print Email Facebook Twitter The role of biocatalysis in the asymmetric synthesis of alkaloids Title The role of biocatalysis in the asymmetric synthesis of alkaloids Author Schrittwieser, J.H. Resch, V. Faculty Applied Sciences Department Biotechnology Date 2013-06-28 Abstract Alkaloids are not only one of the most intensively studied classes of natural products, their wide spectrum of pharmacological activities also makes them indispensable drug ingredients in both traditional and modern medicine. Among the methods for their production, biotechnological approaches are gaining importance, and biocatalysis has emerged as an essential tool in this context. A number of chemo-enzymatic strategies for alkaloid synthesis have been developed over the years, in which the biotransformations nowadays take an increasingly ‘central’ role. This review summarises different applications of biocatalysis in the asymmetric synthesis of alkaloids and discusses how recent developments and novel enzymes render innovative and efficient chemo-enzymatic production routes possible. Subject Gold for GoldOpen Access To reference this document use: http://resolver.tudelft.nl/uuid:533438e0-7e28-41ff-b7ed-03bcfe051cb0 DOI https://doi.org/10.1039/C3RA42123F Publisher RSC Publishing ISSN 2046-2069 Source RSC Advances, 2013,3 Part of collection Institutional Repository Document type journal article Rights (c) 2013 RSC Files PDF c3ra42123f.pdf 3.52 MB Close viewer /islandora/object/uuid:533438e0-7e28-41ff-b7ed-03bcfe051cb0/datastream/OBJ/view