Print Email Facebook Twitter Synthetic Genomics From a Yeast Perspective Title Synthetic Genomics From a Yeast Perspective Author Koster, C.C. (TU Delft BT/Industriele Microbiologie) Postma, E.D. (TU Delft BT/Industriele Microbiologie) Knibbe, E. (TU Delft BT/Industriele Microbiologie) Cleij, C.V. (TU Delft BN/Christophe Danelon Lab) Daran-Lapujade, P.A.S. (TU Delft BT/Industriele Microbiologie) Date 2022 Abstract Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories. Currently, progress in Synthetic Genomics is hindered by the inability to synthesize DNA molecules longer than a few hundred base pairs, while the size of the smallest genome of a self-replicating cell is several hundred thousand base pairs. Methods to assemble small fragments of DNA into large molecules are therefore required. Remarkably powerful at assembling DNA molecules, the unicellular eukaryote Saccharomyces cerevisiae has been pivotal in the establishment of Synthetic Genomics. Instrumental in the assembly of entire genomes of various organisms in the past decade, the S. cerevisiae genome foundry has a key role to play in future Synthetic Genomics developments. Subject DNA assemblygenome foundrySaccharomyces cerevisiae (Baker’s yeast)synthetic cellssynthetic genomicsyeast To reference this document use: http://resolver.tudelft.nl/uuid:54aded9d-1a49-4ce3-98f5-b745291d94dc DOI https://doi.org/10.3389/fbioe.2022.869486 ISSN 2296-4185 Source Frontiers in Bioengineering and Biotechnology, 10 Part of collection Institutional Repository Document type review Rights © 2022 C.C. Koster, E.D. Postma, E. Knibbe, C.V. Cleij, P.A.S. Daran-Lapujade Files PDF fbioe_10_869486.pdf 1.24 MB Close viewer /islandora/object/uuid:54aded9d-1a49-4ce3-98f5-b745291d94dc/datastream/OBJ/view