Print Email Facebook Twitter Upscaling between an agent-based model (smoothed particle approach) and a continuum-based model for skin contractions Title Upscaling between an agent-based model (smoothed particle approach) and a continuum-based model for skin contractions Author Peng, Q. (TU Delft Numerical Analysis; Universiteit Leiden; University of Hasselt) Vermolen, F.J. (TU Delft Numerical Analysis; University of Hasselt) Date 2022 Abstract Skin contraction is an important biophysical process that takes place during and after recovery of deep tissue injury. This process is mainly caused by fibroblasts (skin cells) and myofibroblasts (differentiated fibroblasts which exert larger pulling forces and produce larger amounts of collagen) that both exert pulling forces on the surrounding extracellular matrix (ECM). Modelling is done in multiple scales: agent-based modelling on the microscale and continuum-based modelling on the macroscale. In this manuscript we present some results from our study of the connection between these scales. For the one-dimensional case, we managed to rigorously establish the link between the two modelling approaches for both closed-form solutions and finite-element approximations. For the multi-dimensional case, we computationally evidence the connection between the agent-based and continuum-based modelling approaches. Subject Agent-based modellingContinuum-based modellingFinite-element methodsMechanicsSmoothed particle approachTraction forces To reference this document use: http://resolver.tudelft.nl/uuid:569f96fa-c3d1-401a-8d98-16b0ae4d60de DOI https://doi.org/10.1007/s00285-022-01770-y ISSN 0303-6812 Source Journal of Mathematical Biology, 85 (3) Part of collection Institutional Repository Document type journal article Rights © 2022 Q. Peng, F.J. Vermolen Files PDF s00285_022_01770_y.pdf 3.65 MB Close viewer /islandora/object/uuid:569f96fa-c3d1-401a-8d98-16b0ae4d60de/datastream/OBJ/view