Print Email Facebook Twitter HiveArcs - Visualizing genome co-expression data Title HiveArcs - Visualizing genome co-expression data Author Van den Brink, L.O. Contributor Vilanova, A. (mentor) Faculty Electrical Engineering, Mathematics and Computer Science Department Computer Graphics Programme Medical Visualization Date 2014-10-10 Abstract The developing human brain is a complex process, governed by the human genome. Understanding this development process is the key to understanding not only the connections between genes and brain functioning, but can also advance knowledge about disorders such as Alzheimer’s and Autism. The BrainSpan transcriptional atlas, released in 2013 by the Allen Institute for Brain Science, provides unique opportunities to study this process, but also challenges existing methods for visual analysis. One particular problem arises when large co-expression networks are subdivided in modules through clustering algorithms. In this work we introduce HiveArcs, an interactive online visual analysis for genome co-expression data. HiveArcs visualizes modules using arc diagrams on radially placed axes. Using this lay-out accommodates display of per-gene tracks of additional information as well as relationships between modules. This allows for quick and intuitive comparison between modules as well as in depth analysis of a single module. Subject Computer ScienceVisualizationGene expressionAllen Brain AtlasBrainspanco-expression networksAutismArc diagramBrain To reference this document use: http://resolver.tudelft.nl/uuid:57a4f0b4-2cb1-4a57-90ab-d42ad6609a59 Part of collection Student theses Document type master thesis Rights (c) 2014 Van den Brink, L.O. Files PDF Thesis_Lennaert_van_den_Brink.pdf 117.37 MB Close viewer /islandora/object/uuid:57a4f0b4-2cb1-4a57-90ab-d42ad6609a59/datastream/OBJ/view