Print Email Facebook Twitter Co-expression Network Analysis of the Developing Human Brain Implicates Synaptogenesis and Mitochondrial Function as Central Mechanisms in Autism Title Co-expression Network Analysis of the Developing Human Brain Implicates Synaptogenesis and Mitochondrial Function as Central Mechanisms in Autism Author Mahfouz, A.M.E.T.A. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Ziats, Mark N. (National Institute of Child Health and Human Development, National Institutes of Health; University of Cambridge; Baylor College of Medicine) Rennert, Owen M. (National Institute of Child Health and Human Development, National Institutes of Health) Lelieveldt, B.P.F. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics) Date 2013 Abstract We analyzed the spatial-temporal co-expression relationships of 455 genes previously implicated in Autism spectrum disorder (ASD) using the BrainSpan transcriptome atlas. Understanding how the heterogenous set of ASD-related genes contribute to normal brain development helps identifying cellular/molecular processes which are commonly disrupted in ASD. First, we discovered modules among ASD candidates with biologically relevant temporal co-expression dynamics. These modules were related to the processes of synaptogenesis, apoptosis, and the neurotransmitter y-aminobutyric acid (GABA). Second, we created a transcriptome-wide co-expression network to discover significant Molecular Interaction Modules, and demonstrated that ASD candidate genes are enriched in modules related to the processes of synaptogenesis, mitochondrial function, protein translation, and ubiquitination. Finally, we identified hub genes within the ASD-enriched Molecular Interaction Modules, which may serve as additional ASD candidate genes, potential biomarkers, or therapeutic targets. To reference this document use: http://resolver.tudelft.nl/uuid:57f8dc33-73f7-40d3-afab-c78d36e0ef36 Page numbers 1-1 Part of collection Institutional Repository Document type poster Rights © 2013 A.M.E.T.A. Mahfouz, Mark N. Ziats, Owen M. Rennert, B.P.F. Lelieveldt, M.J.T. Reinders Files PDF Ahmed_CSHL_Poster.pdf 6.65 MB Close viewer /islandora/object/uuid:57f8dc33-73f7-40d3-afab-c78d36e0ef36/datastream/OBJ/view