A model for controlled dosing of femto-litre volume liquids using hollow microcantilever

A model for controlled dosing of femto-litre volume liquids using hollow microcantilever

Cao, Xi (Student TU Delft)
Gruiter, Rick de (Student TU Delft)
van Oorschot, Ralph (MA3 Solutions B.V.)
Baldi, S. (TU Delft Team Bart De Schutter)
Hassan HosseinNia, S. (TU Delft Mechatronic Systems Design)
Ghatkesar, M.K. (TU Delft Micro and Nano Engineering)

2017

A hollow microcantilever is used instead of a conventional microcantilever to dispense and aspirate liquids in the femto-litre (10^-15 L) volume range in an atomic force microscope (AFM) setup. The inherent force sensing capability of the cantilever is used to monitor the fluid manipulation in-situ. At this small scale, parameters like: surface energy, evaporation, viscosity and temperature become important for controlled manipulation. In a conventional AFM, these parameters are usually not taken into consideration as feedback parameters. In the present work, we report initial experimental results on the dosing process and an analytical dynamic model of the process. The model is based on the liquid bridge between the cantilever tip and the substrate, which can describe the dosing process with variance accounted for (VAF) larger than 90%. We aim to use this model and implement a control system for precise dispensing and aspiration.

Atomic Force Microscope
dynamic modelling
femto-liter
hollow-cantilever
nanotechnology

http://resolver.tudelft.nl/uuid:5b27f6fb-e914-4101-b753-4aa40119f574

https://doi.org/10.1016/j.ifacol.2017.08.2141

2405-8963

IFAC-PapersOnLine, 50 (1), 15542-15547

20th World Congress of the International Federation of Automatic Control (IFAC), 2017, 2017-07-09 → 2017-07-14, Toulouse, France

Institutional Repository

journal article

© 2017 Xi Cao, Rick de Gruiter, Ralph van Oorschot, S. Baldi, S. Hassan HosseinNia , M.K. Ghatkesar