Print Email Facebook Twitter Improved image quality using monolithic scintillator detectors with dual-sided readout in a whole-body TOF-PET ring Title Improved image quality using monolithic scintillator detectors with dual-sided readout in a whole-body TOF-PET ring: A simulation study Author Tabacchini, V. (TU Delft RST/Applied Radiation & Isotopes) Surti, Suleman (University of Pennsylvania) Borghi, G. (TU Delft RST/Applied Radiation & Isotopes) Karp, Joel S. (University of Pennsylvania) Schaart, D.R. (TU Delft RST/Applied Radiation & Isotopes) Date 2017-02-13 Abstract We have recently built and characterized the performance of a monolithic scintillator detector based on a 32 mm × 32 mm × 22 mm LYSO:Ce crystal read out by digital silicon photomultiplier (dSiPM) arrays coupled to the crystal front and back surfaces in a dual-sided readout (DSR) configuration. The detector spatial resolution appeared to be markedly better than that of a detector consisting of the same crystal with conventional back-sided readout (BSR). Here, we aim to evaluate the influence of this difference in the detector spatial response on the quality of reconstructed images, so as to quantify the potential benefit of the DSR approach for high-resolution, whole-body time-of-flight (TOF) positron emission tomography (PET) applications. We perform Monte Carlo simulations of clinical PET systems based on BSR and DSR detectors, using the results of our detector characterization experiments to model the detector spatial responses. We subsequently quantify the improvement in image quality obtained with DSR compared to BSR, using clinically relevant metrics such as the contrast recovery coefficient (CRC) and the area under the localized receiver operating characteristic curve (ALROC). Finally, we compare the results with simulated rings of pixelated detectors with DOI capability. Our results show that the DSR detector produces significantly higher CRC and increased ALROC values than the BSR detector. The comparison with pixelated systems indicates that one would need to choose a crystal size of 3.2 mm with three DOI layers to match the performance of the BSR detector, while a pixel size of 1.3 mm with three DOI layers would be required to get on par with the DSR detector. Subject contrastdepth of interaction (DOI)digital silicon photomultiplier (dSiPM)image qualitylesion detectabilitymonolithic scintillator detectortime-of-flight positron emission tomography (TOF-PET) To reference this document use: http://resolver.tudelft.nl/uuid:6260f6c4-5e4c-419e-8652-182a8c1893a3 DOI https://doi.org/10.1088/1361-6560/aa56e1 ISSN 0031-9155 Source Physics in Medicine and Biology, 62 (5), 2018-2032 Part of collection Institutional Repository Document type journal article Rights © 2017 V. Tabacchini, Suleman Surti, G. Borghi, Joel S. Karp, D.R. Schaart Files PDF Tabacchini_2017_Phys._Med ... 2_2018.pdf 1.99 MB Close viewer /islandora/object/uuid:6260f6c4-5e4c-419e-8652-182a8c1893a3/datastream/OBJ/view