Print Email Facebook Twitter Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions Title Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions Author Mahfouz, A.M.E.T.A. (TU Delft Pattern Recognition and Bioinformatics) Lelieveldt, B.P.F. (TU Delft Pattern Recognition and Bioinformatics) Grefhorst, Aldo (Erasmus MC) Mol, Isabel M. (Leiden University Medical Center) Sips, Hetty C.M. (Leiden University Medical Center) van den Heuvel, José K. (Leiden University Medical Center) Visser, Jenny A. (Erasmus MC) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics) Meijer, Onno C. (Leiden University Medical Center) Date 2015 Abstract Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings. To reference this document use: http://resolver.tudelft.nl/uuid:62f5f31f-d655-4732-954b-9ffd7614939f Page numbers 1 Part of collection Institutional Repository Document type poster Rights © 2015 A.M.E.T.A. Mahfouz, B.P.F. Lelieveldt, Aldo Grefhorst, Isabel M. Mol, Hetty C.M. Sips, José K. van den Heuvel, Jenny A. Visser, M.J.T. Reinders, Onno C. Meijer, More Authors Files PDF ahmedmafouz_december_2015.pdf 24.47 MB Close viewer /islandora/object/uuid:62f5f31f-d655-4732-954b-9ffd7614939f/datastream/OBJ/view