Print Email Facebook Twitter Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations Title Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations Author Zhang, W. (TU Delft BT/Biocatalysis) Fernandez Fueyo, E. (TU Delft BN/Greg Bokinsky Lab) Ni, Y. (TU Delft BT/Biocatalysis) van Schie, M.M.C.H. (TU Delft BT/Biocatalysis) Gacs, Jenö (Student TU Delft) Renirie, R. (TU Delft BT/Biocatalysis; Universiteit van Amsterdam) Wever, Ron (Universiteit van Amsterdam) Mutti, Francesco G. (Universiteit van Amsterdam) Rother, Dörte (Forschungszentrum Jülich GmbH) Alcalde, Miguel (Instituto de Microelectronica de Madrid (CSIC)) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2018 Abstract Peroxygenases offer an attractive means to address challenges in selective oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant H2O2. Often atom-inefficient peroxide generation systems are required, which show little potential for large-scale implementation. Here, we show that visible-light-driven, catalytic water oxidation can be used for in situ generation of H2O2 from water, rendering the peroxygenase catalytically active. In this way, the stereoselective oxyfunctionalization of hydrocarbons can be achieved by simply using the catalytic system, water and visible light. To reference this document use: http://resolver.tudelft.nl/uuid:6449de96-ebee-4161-a1fc-5b317047c446 DOI https://doi.org/10.1038/s41929-017-0001-5 Embargo date 2019-06-30 Source Nature Catalysis, 1 (1), 55-62 Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2018 W. Zhang, E. Fernandez Fueyo, Y. Ni, M.M.C.H. van Schie, Jenö Gacs, R. Renirie, Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde, F. Hollmann Files PDF s41929_017_0001_5.pdf 3.36 MB Close viewer /islandora/object/uuid:6449de96-ebee-4161-a1fc-5b317047c446/datastream/OBJ/view