Gamma-Ray mutagenesis in bacteriophage T4 is not enhanced by oxygen
article
As in the induction of r mutants in bacteriophage T4 by ??-rays, the radiation-induced reversion of T4 amber mutants to wild-type was found to depend on the product of the DNA-repair gene x of the phage. Neither the efficiency of induction of r mutants nor the efficiency of reversion of ambers was enhanced by the presence of oxygen during irradiation. T4 differed in this respect from phage T7, for which no indication has been found that ??-ray mutagenesis results from error-prone repair of DNA damage. Notwithstanding the substantial contribution of misrepair to mutation induction in T4, the efficiency of induction per base-pair observed for irradiation under oxygen was lower than that found previously for T7. Chemicals/CAS: oxygen, 7782-44-7; DNA, Viral; Mutagens; Oxygen, 7782-44-7
Topics
TNO Identifier
228642
Source
Mutation Research, 61(2), pp. 121-127.
Pages
121-127
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