Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Ghafaryasl, B. (TU Delft ImPhys/Quantitative Imaging; Rotterdam Ophthalmic Institute; Rotterdam Eye Hospital)
Vermeer, K.A. (Rotterdam Ophthalmic Institute; Rotterdam Eye Hospital)
Kalkman, J. (TU Delft ImPhys/Quantitative Imaging)
Dore-Callewaert, T.W.J. (TU Delft (OLD) MSE-4)
de Boer, J.F. (Vrije Universiteit Amsterdam)
van Vliet, L.J. (TU Delft ImPhys/Quantitative Imaging)

Izatt, Joseph A. (editor)
Fujimoto, James G. (editor)
Tuchin, Valery V. (editor)

2018

The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.

attenuation coefficient
beam-shape
Cramér-Rao lower bound
focus
OCT
point spread function
Rayleigh length

http://resolver.tudelft.nl/uuid:6936b75f-32d9-427b-a254-77e4a303224a

https://doi.org/10.1117/12.2292002

SPIE, Bellingham, WA, USA

2018-08-14

9781510614512

Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 10483

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018, 2018-01-29 → 2018-01-31, San Francisco, United States

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Institutional Repository

conference paper

© 2018 B. Ghafaryasl, K.A. Vermeer, J. Kalkman, T.W.J. Dore-Callewaert, J.F. de Boer, L.J. van Vliet