Print Email Facebook Twitter A photo-enzymatic cascade to transform racemic alcohols into enantiomerically pure amines Title A photo-enzymatic cascade to transform racemic alcohols into enantiomerically pure amines Author Gacs, Jenő (Student TU Delft) Zhang, W. (TU Delft BT/Biocatalysis) Knaus, Tanja (Universiteit van Amsterdam) Mutti, Francesco G. (Universiteit van Amsterdam) Arends, I.W.C.E. (TU Delft BT/Biocatalysis) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2019 Abstract The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω-transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade. Subject AlcoholCascadePhotooxidationReductive aminationω-transaminase To reference this document use: http://resolver.tudelft.nl/uuid:6c3e20bf-06b4-4881-b743-4f4d06f7c7b6 DOI https://doi.org/10.3390/catal9040305 ISSN 2073-4344 Source Catalysts, 9 (4) Part of collection Institutional Repository Document type journal article Rights © 2019 Jenő Gacs, W. Zhang, Tanja Knaus, Francesco G. Mutti, I.W.C.E. Arends, F. Hollmann Files PDF catalysts_09_00305_v2.pdf 1.17 MB Close viewer /islandora/object/uuid:6c3e20bf-06b4-4881-b743-4f4d06f7c7b6/datastream/OBJ/view