Prolonged Ex vivo Preservation

Prolonged Ex vivo Preservation: Creating a Normothermic Machine Perfusion Setup

Brouwer, Max (TU Delft Mechanical, Maritime and Materials Engineering; TU Delft Biomechanical Engineering)

Dankelman, J. (mentor)
Goos, T.G. (graduation committee)
Apachitei, I. (graduation committee)

Delft University of Technology

Biomedical Engineering

2019-02-13

Expanded Criteria Donor (ECD) organs are being used more often in clinical setting. The regenerative ability of the organs might be able to restore the organ to full functionality ex vivo. For long term kidney stabilization, optimization and monitoring an organ incubator is preferable. However, it is unclear which available parts would work best in synergy. A Normothermic Machine Perfusion (NMP) setup and a Mathematical Windkessel Model were created as a first step in a larger project of prolonged preservation of ECD organs. While the current NMP setup was found adequate for academic research, it can only be used for simple studies using water. Several fundamental improvements need to be made before the setup can be used as a fully functioning NMP setup for kidneys. Key improvements would be the addition of a Windkessel and a different cardiac pump.

Normothermic Machine Perfusion
Kidney Transplantation
Windkessel
Organ Preservation
Ex Vivo
Expanded Criteria Donor
Kidney Preservation

http://resolver.tudelft.nl/uuid:71b70c24-726d-47f8-ba54-45864bccd0ef

Student theses

master thesis

© 2019 Max Brouwer