Print Email Facebook Twitter From industrial fermentor to CFD-guided downscaling Title From industrial fermentor to CFD-guided downscaling: what have we learned? Author Haringa, C. (TU Delft ChemE/Transport Phenomena; DSM) Mudde, R.F. (TU Delft ImPhys/Imaging Physics; TU Delft Executive board; TU Delft ChemE/Transport Phenomena) Noorman, H.J. (TU Delft BT/Bioprocess Engineering; DSM) Department ImPhys/Imaging Physics Date 2018 Abstract Euler–Lagrange computational fluid dynamics simulations offer great potential for the integration of transport dynamics and metabolic dynamics in fermentation systems. Since the seminal work of Lapin et al. [1,2], progress has been made, mainly in the analysis of CFD data and translation to laboratory setup designs. Different large-scale processes require different analysis methods; in this paper we discuss which analysis methods are best suited for given reactor types, by reviewing prior simulation cases as well as introducing new test cases. Furthermore, we address challenges in the translation from Euler–Lagrange simulations to laboratory scale systems, and propose methods to work around these shortcomings. Based on the current state of the art, we propose guidelines for the selection of data analysis methods, and we discuss the design of rational scale-down simulators. We conclude with a brief discussion regarding the requirements and possibilities of next-generation scale-down simulators, such as microfluidic single-cell analysis, and possible ways to approximate cellular lifelines from invasive intra-cellular measurements. Subject CFDDownscalingEuler–LagrangeFermentationMetabolic modeling To reference this document use: http://resolver.tudelft.nl/uuid:754bf9bd-8a0f-42c8-925e-91b10aef7e5e DOI https://doi.org/10.1016/j.bej.2018.09.001 Embargo date 2019-03-08 ISSN 1369-703X Source Biochemical Engineering Journal, 140, 57-71 Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2018 C. Haringa, R.F. Mudde, H.J. Noorman Files PDF 1_s2.0_S1369703X18303127.pdf 3.7 MB Close viewer /islandora/object/uuid:754bf9bd-8a0f-42c8-925e-91b10aef7e5e/datastream/OBJ/view