In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic

In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic

Wang, S. (Chinese Academy of Sciences; Shanghai Institute of Technology)
Xu, Y. (Shanghai Jiao Tong University)
Zhou, J. (TU Delft Biomaterials & Tissue Biomechanics)
Li, H. (Shanghai Jiao Tong University)
Chang, Jiang (Chinese Academy of Sciences)
Huan, Z. (Chinese Academy of Sciences)

2017

Iron-matrix composites with calcium silicate (CS) bioceramic as the reinforcing phase were fabricated through powder metallurgy processes. The microstructures, mechanical properties, apatite deposition and biodegradation behavior of the Fe-CS composites, as well as cell attachment and proliferation on
their surfaces, were characterized. In the range of CS weight percentages selected in this study, the composites possessed compact structures and showed differently decreased bending strengths as compared with pure iron. Immersion tests in simulated body fluid (SBF) revealed substantially enhanced deposition of CaP on the surfaces of the composites as well as enhanced degradation rates as compared with pure iron. In addition, the composite containing 20% CS showed a superior ability to stimulate hBMSCs proliferation when compared to pure iron. Our results suggest that incorporating calcium silicate particles into iron could be an effective approach to developing iron-based biodegradable bone implants with improved biomedical performance.

http://resolver.tudelft.nl/uuid:760a68ec-7737-42c2-af54-596c1d5bf5bd

https://doi.org/10.1016/j.bioactmat.2016.12.001

2452-199X

Bioactive Materials, 2 (1), 10-18

Institutional Repository

journal article

© 2017 S. Wang, Y. Xu, J. Zhou, H. Li, Jiang Chang, Z. Huan