Print Email Facebook Twitter Membrane mediated interactions and pattern formation of conical inclusions on a flat membrane Title Membrane mediated interactions and pattern formation of conical inclusions on a flat membrane Author Vos, Roel (TU Delft Applied Sciences; TU Delft Electrical Engineering, Mathematics and Computer Science) Contributor Idema, T. (mentor) Dubbeldam, J.L.A. (mentor) van der Heul, D.R. (graduation committee) Beaumont, H.J.E. (mentor) Degree granting institution Delft University of Technology Programme Applied Mathematics | Applied Physics Date 2018-08-23 Abstract In this thesis, we investigate interactions between conical inclusions in a lipid bilayer membrane and make predictions about the patterns they form. To find these patterns, we derive an expression for the energy of a membrane as a function of the inclusion locations and search numerically for the patternthat gives minimum energy.The energy of a membrane with conical inclusions can be derived using the point particles model with corresponding formalism developed by Dommersnes and Fournier [1]. In this thesis, we apply this formalism to the finite size particles model described by Weikl et al. [2]. We compare the results of bothmodels for a system of three inclusions, to validate the point particles model’s ability to accurately predict equilibrium patterns for conical inclusions. For most non-conical inclusions, however, the point particles model proves inadequate, leaving only the computationally intensive finite size particles model to be used for more complex inclusions.We develop a new numerical method for finding equilibrium patterns: the gradient descent method. This method is several hundred times faster than the standard Metropolis algorithm, and gives acceptable results. For large systems of inclusions, the method is very sensitive to local minima and has difficultiesmerging small groups. The addition of noise in the Brownian motion method proves to be unable to resolve the local minima sensitivity, but we speculate that small bursts of high noise or grouping stable inclusions structures and moving the groups as a whole may be more effective. Using the point particles model, we found that four-inclusion square-shaped structures and six-inclusion butterfly-shaped structures are favored in all systems with more than six inclusions. Subject Lipid membraneConical inclusionsPoint Particles ModelFinite Size Particles ModelGradient Descent algorithm To reference this document use: http://resolver.tudelft.nl/uuid:78f026fe-e68f-43db-b230-8943e74369cb Part of collection Student theses Document type bachelor thesis Rights © 2018 Roel Vos Files PDF Bachelor_thesis_Roel_Vos.pdf 2.36 MB Close viewer /islandora/object/uuid:78f026fe-e68f-43db-b230-8943e74369cb/datastream/OBJ/view