Print Email Facebook Twitter Role of Biocatalysis in Sustainable Chemistry Title Role of Biocatalysis in Sustainable Chemistry Author Sheldon, R.A. (TU Delft BT/Biocatalysis; University of Witwatersrand) Woodley, John M. (Technical University of Denmark) Date 2018-01-24 Abstract Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology. This is largely a result of the spectacular advances in molecular biology and biotechnology achieved in the past two decades. Protein engineering has enabled the optimization of existing enzymes and the invention of entirely new biocatalytic reactions that were previously unknown in Nature. It is now eminently feasible to develop enzymatic transformations to fit predefined parameters, resulting in processes that are truly sustainable by design. This approach has successfully been applied, for example, in the industrial synthesis of active pharmaceutical ingredients. In addition to the use of protein engineering, other aspects of biocatalysis engineering, such as substrate, medium, and reactor engineering, can be utilized to improve the efficiency and cost-effectiveness and, hence, the sustainability of biocatalytic reactions. Furthermore, immobilization of an enzyme can improve its stability and enable its reuse multiple times, resulting in better performance and commercial viability. Consequently, biocatalysis is being widely applied in the production of pharmaceuticals and some commodity chemicals. Moreover, its broader application will be further stimulated in the future by the emerging biobased economy. To reference this document use: http://resolver.tudelft.nl/uuid:7b7f9657-ba0a-4774-8e3f-c17ff139c427 DOI https://doi.org/10.1021/acs.chemrev.7b00203 Embargo date 2019-01-24 ISSN 0009-2665 Source Chemical Reviews, 118 (2), 801-838 Bibliographical note Accepted Author Manuscript Part of collection Institutional Repository Document type review Rights © 2018 R.A. Sheldon, John M. Woodley Files PDF Role_of_Biocatalysis_in_S ... istry_.pdf 4.88 MB Close viewer /islandora/object/uuid:7b7f9657-ba0a-4774-8e3f-c17ff139c427/datastream/OBJ/view