Print Email Facebook Twitter NeuroControl of movement: System identification approach for clinical benefit Title NeuroControl of movement: System identification approach for clinical benefit Author Meskers, C.G.M. De Groot, J. De Vlugt, E. Schouten, A.C. Faculty Mechanical, Maritime and Materials Engineering Department Biomechanical Engineering Date 2015-09-08 Abstract Progress in diagnosis and treatment of movement disorders after neurological diseases like stroke, cerebral palsy (CP), dystonia and at old age requires understanding of the altered capacity to adequately respond to physical obstacles in the environment. With posture and movement disorders, the control of muscles is hampered, resulting in aberrant force generation and improper impedance regulation. Understanding of this improper regulation not only requires the understanding of the role of the neural controller, but also attention for: (1) the interaction between the neural controller and the “plant”, comprising the biomechanical properties of the musculaskeletal system including the viscoelastic properties of the contractile (muscle) and non-contractile (connective) tissues: neuromechanics; and (2) the closed loop nature of neural controller and biomechanical system in which cause and effect interact and are hence difficult to separate. Properties of the neural controller and the biomechanical system need to be addressed synchronously by the combination of haptic robotics, (closed loop) system identification (SI), and neuro-mechanical modeling. In this paper, we argue that assessment of neuromechanics in response to well defined environmental conditions and tasks may provide for key parameters to understand posture and movement disorders in neurological diseases and for biomarkers to increase accuracy of prediction models for functional outcome and effects of intervention. Subject afferent feedback modulationneuromechanicssystem identificationageingstrokemovement disorders To reference this document use: http://resolver.tudelft.nl/uuid:7b8a8c2f-9c46-4a69-a97c-424ae56dd4a5 Publisher Frontiers ISSN 1662-5145 Source https://doi.org/10.3389/fnint.2015.00048 Source Frontiers in Integrative Neuroscience, 9, 2015 Part of collection Institutional Repository Document type journal article Rights © 2015 The Author(s)This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Files PDF deVlugt_2015.pdf 922.86 KB Close viewer /islandora/object/uuid:7b8a8c2f-9c46-4a69-a97c-424ae56dd4a5/datastream/OBJ/view