Print Email Facebook Twitter Polarization contrast optical diffraction tomography Title Polarization contrast optical diffraction tomography Author van Rooij, J. (TU Delft ImPhys/Computational Imaging) Kalkman, J. (TU Delft ImPhys/Computational Imaging) Date 2020 Abstract We demonstrate large scale polarization contrast optical diffraction tomography (ODT). In cross-polarized sample arm detection configuration we determine, from the amplitude of the optical wavefield, a relative measure of the birefringence projection. In parallel-polarized sample arm detection configuration we image the conventional phase projection. For off-axis sample placement we observe for polarization contrast ODT, similar as for phase contrast ODT, a strongly reduced noise contribution. In the limit of small birefringence phase shift δ we demonstrate tomographic reconstruction of polarization contrast images into a full 3D image of an optically cleared zebrafish. The polarization contrast ODT reconstruction shows muscular zebrafish tissue, which cannot be visualized in conventional phase contrast ODT. Polarization contrast ODT images of the zebrafish show a much higher signal to noise ratio (SNR) than the corresponding phase contrast images, SNR=73 and SNR=15, respectively. To reference this document use: http://resolver.tudelft.nl/uuid:7eaf9850-bb7c-4aca-983a-186c488fcf01 DOI https://doi.org/10.1364/BOE.381992 ISSN 2156-7085 Source Biomedical Optics Express, 11 (4), 2109-2121 Part of collection Institutional Repository Document type journal article Rights © 2020 J. van Rooij, J. Kalkman Files PDF boe_11_4_2109.pdf 7.66 MB Close viewer /islandora/object/uuid:7eaf9850-bb7c-4aca-983a-186c488fcf01/datastream/OBJ/view