Print Email Facebook Twitter Structural and mechanical characterization of the peri-prosthetic fibrous membrane Title Structural and mechanical characterization of the peri-prosthetic fibrous membrane Author Moerman, A.M. Contributor Valstar, E.R. (mentor) Zadpoor, A.A. (mentor) Faculty Mechanical, Maritime and Materials Engineering Department BioMechanical Engineering Programme BME Date 2015-04-16 Abstract In this pilot study, we obtained the peri-prosthetic fibrous membrane of eleven patients undergoing hip revision surgery due to aseptic loosening. We investigated the molecular content of the tissue by real-time PCR (RT-PCR) and the structural properties by histology and confocal microscopy. Atomic force microscopy (AFM) and nanoindentation were used to determine the mechanical properties of the peri-prosthetic tissue, respectively at the nano- and microscopic scale. Finally, the AFM data was evaluated using the statistical finite mixture models theory, to link the contributions of different constituents of this heterogeneous tissue to the measured mechanical properties To reference this document use: http://resolver.tudelft.nl/uuid:801442a5-b4dc-4422-97e2-1c7cbae22625 Embargo date 2016-04-16 Part of collection Student theses Document type master thesis Rights (c) 2015 Moerman, A.M. Files PDF Thesis_Astrid_Moerman.pdf 19.51 MB Close viewer /islandora/object/uuid:801442a5-b4dc-4422-97e2-1c7cbae22625/datastream/OBJ/view