Next-generation neutron capture therapy

Next-generation neutron capture therapy

Garretsen, Astrid (TU Delft Mechanical, Maritime and Materials Engineering)

Denkova, A.G. (mentor)
Vogel, Wouter (mentor)
Wolterbeek, H.T. (graduation committee)
Djanashvili, K. (graduation committee)

Delft University of Technology

2018-05-22

Neutron capture therapy (NCT) is a binary form of radiotherapy that utilizes the high cross section of some nonradioactive elements, in particular boron-10 and gadolinium-157, for thermal neutron capture. The energetic charged particles (electrons and alpha particles) released in the capture reaction cause a high localized deposition. For almost a century, NCT has been regarded as the holy grail of targeted radiotherapy, but its superiority over other available treatments has not been demonstrated so far. Limitations included amongst others a poor and non-selective biodistribution of Boron carrier molecules, the limited availability of suitable neutron sources, a lack of tools for patient selection and individualized dosimetry, and a shortage of properly conducted clinical trials.

Neutron capture therapy
Boron
gadolinium

http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b

2020-05-22

Student theses

master thesis

© 2018 Astrid Garretsen