Print Email Facebook Twitter CMOS Image Sensor for Lateral Flow Immunoassay Readers Title CMOS Image Sensor for Lateral Flow Immunoassay Readers Author Pilavaki, Evdokia (University College London (UCL)) Valente, V. (TU Delft Bio-Electronics; University College London (UCL)) Demosthenous, Andreas (University College London (UCL)) Date 2018 Abstract Point-of-care systems for the detection of infectious diseases are in great demand especially in developing countries. Lateral flow immunoassays are considered ideal biosensors for point-of-care diagnostics due to their numerous advantages. However, to quantify their results a low power, robust electronic reader is needed. A low power CMOS image sensor is presented that can be used in quantitative lateral flow immunoassay readers. It uses a single low power processing capacitive transimpedance amplifier architecture which includes noise cancellation. A chip containing 4 × 64 pixels was fabricated in CMOS 0.35-μm technology. With uniform illumination at 525 nm and 67 frames per second the chip has 1.9 mVrms total output referred noise and a total power consumption of 21 μW. In tests with lateral flow immunoassays the chip detected concentrations of influenza A nucleoprotein from 0.5 ng/mL to 200 ng/mL. Subject capacitive transimpedance amplifierCMOS image sensorImmune systemInfluenzalateral flow immunoassaysLogic gatesNoise cancellationPhotoconductivitypoint-of-care.Semiconductor device measurementSwitches To reference this document use: http://resolver.tudelft.nl/uuid:81950b54-bd80-4d30-940d-03d61a3c5fdb DOI https://doi.org/10.1109/TCSII.2018.2855054 ISSN 1549-7747 Source IEEE Transactions on Circuits and Systems Part 2: Express Briefs, 62 (10), 1405-1409 Part of collection Institutional Repository Document type journal article Rights © 2018 Evdokia Pilavaki, V. Valente, Andreas Demosthenous Files PDF 46609053_08410928.pdf 1.5 MB Close viewer /islandora/object/uuid:81950b54-bd80-4d30-940d-03d61a3c5fdb/datastream/OBJ/view