Print Email Facebook Twitter Alcohol Dehydrogenases Catalyze the Reduction of Thioesters Title Alcohol Dehydrogenases Catalyze the Reduction of Thioesters Author Younes, S.H.H. (TU Delft BT/Biocatalysis; Sohag University) Ni, Y. (TU Delft BT/Biocatalysis) Schmidt, S. (TU Delft BT/Biocatalysis) Kroutil, Wolfgang (Graz University of Technology) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2017-04-21 Abstract Alcohol dehydrogenases are well-established catalysts for various reduction reactions. However, the reduction of carboxylic acid derivatives has not yet been reported with these enzymes. In this contribution, we demonstrated that carboxylic acid thioesters could be readily reduced by a range of alcohol dehydrogenases, albeit at significantly reduced rates relative to those observed for corresponding ketones. A molecular explanation, especially for the lower turnover rates for thioesters relative to those obtained for ketones, is presented, as is a preliminary substrate scope. Subject alcoholsbiocatalysisenzymesreductionthioesters To reference this document use: http://resolver.tudelft.nl/uuid:8e5225d1-75bc-4e71-a55c-71106c4811d9 DOI https://doi.org/10.1002/cctc.201700165 ISSN 1867-3880 Source ChemCatChem, 9 (8), 1389-1392 Bibliographical note Accepted Author Manuscript Part of collection Institutional Repository Document type journal article Rights © 2017 S.H.H. Younes, Y. Ni, S. Schmidt, Wolfgang Kroutil, F. Hollmann Files PDF 10.1002_cctc.201700165.pdf 522.35 KB Close viewer /islandora/object/uuid:8e5225d1-75bc-4e71-a55c-71106c4811d9/datastream/OBJ/view