Print Email Facebook Twitter Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis Title Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis Author Zhang, W. (TU Delft BT/Biocatalysis) Burek, Bastien O. (DECHEMA Research Institute) Fernandez Fueyo, E. (CSIC - Centro de Investigaciones Biologicas (CIB)) Alcalde, Miguel (Institute of Catalysis, CSIC, Madrid) Bloh, Jonathan Z. (DECHEMA Research Institute) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2017-11-27 Abstract Selective oxyfunctionalizations of inert C−H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold–titanium dioxide efficiently provide H2O2 through the methanol-driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was achieved with high enantioselectivity (>98 % ee) and excellent turnover numbers for the biocatalyst (>71 000). Subject BiocatalysisoxyfunctionalizationperoxygenasesphotocatalysisTiO To reference this document use: http://resolver.tudelft.nl/uuid:a08b0b00-d13c-4b6f-a73c-99c5952e0c32 DOI https://doi.org/10.1002/anie.201708668 ISSN 1433-7851 Source Angewandte Chemie (International Edition), 56 (48), 15451-15455 Part of collection Institutional Repository Document type journal article Rights © 2017 W. Zhang, Bastien O. Burek, E. Fernandez Fueyo, Miguel Alcalde, Jonathan Z. Bloh, F. Hollmann Files PDF Zhang_et_al_2017_Angewand ... dition.pdf 1.07 MB Close viewer /islandora/object/uuid:a08b0b00-d13c-4b6f-a73c-99c5952e0c32/datastream/OBJ/view