Perinatal risk indicators for long-term neurological morbidity among preterm neonates
article
Objective: Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age. Study design: Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap. Results: Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after <2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively). Conclusion: In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity. © 2011 Mosby, Inc. All rights reserved.
Topics
long-term neurologic morbidityperinatal risk indicatorprediction modelprematurearticlebrain hemorrhagechilddisabilityenvironmental factorfemalefollow upgestational agehumanmajor clinical studymaleNetherlandsneurologic diseaseprematuritypreschool childpriority journalrespiratory tract diseaserisk factorseizuresmall for date infant
TNO Identifier
429739
ISSN
00029378
Source
American Journal of Obstetrics and Gynecology, 204(5), pp. 396.e1-396.e14.
Pages
396.e1-396.e14
Files
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