Print Email Facebook Twitter Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation Title Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation Author Haringa, C. (TU Delft ChemE/Transport Phenomena) Deshmukh, Amit T. (DSM) Mudde, R.F. (TU Delft ChemE/Transport Phenomena) Noorman, H.J. (TU Delft BT/Bioprocess Engineering) Date 2017-01-23 Abstract With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the process performance. The influence of extra-cellular variations on the organism can be tested using so-called scale-down simulators, laboratory scale setups where deliberate, controlled fluctuations are imposed in the extra-cellular environment. Subject Industrial scaleEuler-LagrangeCFDScale-downFermentation To reference this document use: http://resolver.tudelft.nl/uuid:a87db8f6-c997-4f0e-a177-5afc2925e2b5 DOI https://doi.org/10.1016/j.ces.2017.01.014 ISSN 0009-2509 Source Chemical Engineering Science, 170, 653-669 Part of collection Institutional Repository Document type journal article Rights © 2017 C. Haringa, Amit T. Deshmukh, R.F. Mudde, H.J. Noorman Files PDF 1_s2.0_S0009250917300337_main.pdf 4.34 MB Close viewer /islandora/object/uuid:a87db8f6-c997-4f0e-a177-5afc2925e2b5/datastream/OBJ/view