Print Email Facebook Twitter Real-time photoacoustic assessment of radiofrequency ablation lesion formation in the left atrium Title Real-time photoacoustic assessment of radiofrequency ablation lesion formation in the left atrium Author Iskander-Rizk, Sophinese (Erasmus MC) Kruizinga, P. (Erasmus MC) Beurskens, Robert (Erasmus MC) Springeling, Geert (Erasmus MC) Mastik, Frits (Erasmus MC) de Groot, N.M.S. (Erasmus MC) Knops, Paul (Erasmus MC) van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC) van Soest, Gijs (Erasmus MC) Date 2019 Abstract In interventional electrophysiology, catheter-based radiofrequency (RF) ablation procedures restore cardiac heart rhythm by interrupting aberrant conduction paths. Real-time feedback on lesion formation and post-treatment lesion assessment could overcome procedural challenges related to ablation of underlying structures and lesion gaps. This study aims to evaluate real-time visualization of lesion progression and continuity during intra-atrial ablation with photoacoustic (PA) imaging, using clinically deployable technology. A PA-enabled RF ablation catheter was used to ablate and illuminate porcine left atrium, both excised and intact in a passive beating heart ex-vivo, for photoacoustic signal generation. PA signals were received with an intracardiac echography catheter. Using the ratio of PA images acquired with excitation wavelengths of 790 nm and 930 nm, ablation lesions were successfully imaged through circulating saline and/or blood, and lesion gaps were identified in real-time. PA-based assessment of RF-ablation lesions was successful in a realistic preclinical model of atrial intervention. Subject Atrial fibrillationLesion monitoringPhotoacoustic imagingPhotoacoustic-enabled RF ablation catheterRF ablation To reference this document use: http://resolver.tudelft.nl/uuid:ac0670cc-523e-4ef4-ab4c-3822f0c728e8 DOI https://doi.org/10.1016/j.pacs.2019.100150 ISSN 2213-5979 Source Photoacoustics, 16 Part of collection Institutional Repository Document type journal article Rights © 2019 Sophinese Iskander-Rizk, P. Kruizinga, Robert Beurskens, Geert Springeling, Frits Mastik, N.M.S. de Groot, Paul Knops, A.F.W. van der Steen, Gijs van Soest Files PDF 1_s2.0_S2213597919300734_main.pdf 3.16 MB Close viewer /islandora/object/uuid:ac0670cc-523e-4ef4-ab4c-3822f0c728e8/datastream/OBJ/view