Print Email Facebook Twitter Potential of MRI in radiotherapy mediated by small conjugates and nanosystems Title Potential of MRI in radiotherapy mediated by small conjugates and nanosystems Author Fauzia, R.P. (TU Delft BT/Biocatalysis) Denkova, A.G. (TU Delft RST/Applied Radiation & Isotopes) Djanashvili, K. (TU Delft BT/Biocatalysis) Date 2019 Abstract Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great challenge, especially in the proximity of vital organs. Therefore, imaging plays a key role in tumor staging, accurate target volume delineation, assessment of individual radiation resistance and even personalized dose prescription. From this point of view, radiotherapy might be one of the few therapeutic modalities that relies entirely on high-resolution imaging. Magnetic resonance imaging (MRI) with its superior soft-tissue resolution is already used in radiotherapy treatment planning complementing conventional computed tomography (CT). Development of systems integrating MRI and linear accelerators opens possibilities for simultaneous imaging and therapy, which in turn, generates the need for imaging probeswith therapeutic components. In this review, we discuss the role of MRI in both external and internal radiotherapy focusing on the most important examples of contrast agents with combined therapeutic potential. Subject Contrast agentsGadoliniumIonizing radiationIron oxide nanoparticlesMagnetic resonance imagingRadiosensitizationRelaxivityTheranosticsTherapeutic radionuclides To reference this document use: http://resolver.tudelft.nl/uuid:ac6216c6-e8a3-41f4-a550-0d195fe2df7e DOI https://doi.org/10.3390/inorganics7050059 Source Inorganics, 7 (5) Part of collection Institutional Repository Document type journal article Rights © 2019 R.P. Fauzia, A.G. Denkova, K. Djanashvili Files PDF PhysRevApplied.12.014013.pdf 2.1 MB Close viewer /islandora/object/uuid:ac6216c6-e8a3-41f4-a550-0d195fe2df7e/datastream/OBJ/view