Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles

Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles

Whiting, N.
Hu, J.
Shah, J.V.
Cassidy, M.C.
Cressman, E.
Millward, N.Z.
Menter, D.G.
Marcus, C.M.
Bhattacharya, P.K.

Applied Sciences

QN/Quantum Nanoscience

2015-08-04

Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ?40?minutes—allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.

http://resolver.tudelft.nl/uuid:b75cacc9-9226-4fcb-b227-16043f50acb1

Nature Publishing Group

2045-2322

https://doi.org/10.1038/srep12842

Scientific Reports, 5 (4), 2015

Institutional Repository

journal article

(c) 2015 The Author(s)
CC BY This work is licensed under a Creative Commons Attribution 4.0 International License