Print Email Facebook Twitter A phenomenological model for cell and nucleus deformation during cancer metastasis Title A phenomenological model for cell and nucleus deformation during cancer metastasis Author Chen, J. (TU Delft Numerical Analysis) Weihs, Daphne (Technion) van Dijk, Marcel (Student TU Delft) Vermolen, F.J. (TU Delft Numerical Analysis) Date 2018 Abstract Cell migration plays an essential role in cancer metastasis. In cancer invasion through confined spaces, cells must undergo extensive deformation, which is a capability related to their metastatic potentials. Here, we simulate the deformation of the cell and nucleus during invasion through a dense, physiological microenvironment by developing a phenomenological computational model. In our work, cells are attracted by a generic emitting source (e.g., a chemokine or stiffness signal), which is treated by using Green’s Fundamental solutions. We use an IMEX integration method where the linear parts and the nonlinear parts are treated by using an Euler backward scheme and an Euler forward method, respectively. We develop the numerical model for an obstacle-induced deformation in 2D or/and 3D. Considering the uncertainty in cell mobility, stochastic processes are incorporated and uncertainties in the input variables are evaluated using Monte Carlo simulations. This quantitative study aims at estimating the likelihood for invasion and the length of the time interval in which the cell invades the tissue through an obstacle. Subsequently, the two-dimensional cell deformation model is applied to simplified cancer metastasis processes to serve as a model for in vivo or in vitro biomedical experiments. Subject Cancer metastasisCell deformationCell-based modelMonte Carlo simulationsNucleus deformation To reference this document use: http://resolver.tudelft.nl/uuid:b8217d04-3234-45a3-b72c-f8b468b85f9a DOI https://doi.org/10.1007/s10237-018-1036-5 ISSN 1617-7959 Source Biomechanics and Modeling in Mechanobiology (online), 17 (5), 1429-1450 Part of collection Institutional Repository Document type journal article Rights © 2018 J. Chen, Daphne Weihs, Marcel van Dijk, F.J. Vermolen Files PDF 10.1007_s10237_018_1036_5.pdf 6.48 MB Close viewer /islandora/object/uuid:b8217d04-3234-45a3-b72c-f8b468b85f9a/datastream/OBJ/view