Print Email Facebook Twitter Mathematical modelling of expanded bed adsorption - a perspective on in silico process design Title Mathematical modelling of expanded bed adsorption - a perspective on in silico process design Author Koppejan, V.W. Ferreira, Guilherme (DSM) Lin, Dong Qiang (Zhejiang University) Ottens, M. (TU Delft BT/Bioprocess Engineering) Date 2018 Abstract Expanded bed adsorption (EBA) emerged in the early 1990s in an attempt to integrate the clarification, capture and initial product concentration/purification process. Several mathematical models have been put forward to describe its operation. However, none of the models developed specifically for EBA allows simultaneous prediction of bed hydrodynamics, mass transfer/adsorption and (unwanted) interactions and fouling. This currently limits the development and early optimization of EBA-based separation processes. In multiphase reactor engineering, the use of multiphase computational fluid dynamics has been shown to improve fundamental understanding of fluidized beds. To advance EBA technology, a combination of particle, equipment and process scale models should be used. By employing a cascade of multiscale simulations, the various challenges EBA currently faces can be addressed. This allows for optimal design and selection of equipment, materials and process conditions, and reduces risks and development times of downstream processes involving EBA. Subject BioseparationsChromatographyDownstreamMathematical ModellingProcess Development To reference this document use: http://resolver.tudelft.nl/uuid:c3da7de4-1add-49d9-b216-0f63639abb44 DOI https://doi.org/10.1002/jctb.5595 ISSN 0268-2575 Source Journal of Chemical Technology and Biotechnology, 93 (7), 1815-1826 Part of collection Institutional Repository Document type journal article Rights © 2018 V.W. Koppejan, Guilherme Ferreira, Dong Qiang Lin, M. Ottens Files PDF Koppejan_et_al_2017_Journ ... nology.pdf 1.51 MB Close viewer /islandora/object/uuid:c3da7de4-1add-49d9-b216-0f63639abb44/datastream/OBJ/view