Print Email Facebook Twitter Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review Title Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review Author Bracco Garcia, M.P. (TU Delft BT/Biocatalysis) Busch, H. (TU Delft BT/Biocatalysis) von Langermann, J. Hanefeld, U. (TU Delft BT/Biocatalysis) Date 2016-06-01 Abstract The first enantioselective synthesis was the selective addition of cyanide to benzaldehyde catalysed by a hydroxynitrile lyase (HNL). Since then these enzymes have developed into a reliable tool in organic synthesis. HNLs to prepare either the (R)- or the (S)-enantiomer of the desired cyanohydrin are available and a wide variety of reaction conditions can be applied. As a result of this, numerous applications of these enzymes in organic synthesis have been described. Here the examples of the last decade are summarised, the enzyme catalysed step is discussed and the follow-up chemistry is shown. This proves HNLs to be part of main stream organic synthesis. Additionally the newest approaches via immobilisation and reaction engineering are introduced. Subject Gold for GoldOpen Access To reference this document use: http://resolver.tudelft.nl/uuid:d2fa6ff7-7d21-4839-acd4-4eb6902b161f DOI https://doi.org/10.1039/C6OB00934D ISSN 1477-0520 Source Organic & Biomolecular Chemistry Part of collection Institutional Repository Document type journal article Rights © 2016 M.P. Bracco Garcia, H. Busch, J. von Langermann, U. Hanefeld Files PDF c6ob00934d.pdf 2.28 MB Close viewer /islandora/object/uuid:d2fa6ff7-7d21-4839-acd4-4eb6902b161f/datastream/OBJ/view