This graduation project was initiated as a collaboration with IQ Medical Ventures, a medical incubator situated in Delft. The goal of the project was to design an ergonomic and intuitive handle for Ureca Catheter. Ureca is a device being developed by IQ Medical Ventures, in collaboration with Prof. J. Reekers, interventional radiology professor at Amsterdam Medical Center. Ureca is a loop catheter which uses the P.I.E.R. technique for treating obstructed arteries. PIER is a minimally invasive technique used in interventional radiology for unblocking completely obstructed peripheral arteries. It has the advantages of not requiring complete anesthesia, and having shorter recovery time than the classic bypass. The project was initiated with the problem statement, which was followed by a detailed planning of the project phases. The first phase represented the analysis. The analysis phase had four main parts of focus: the medical analysis, the product analysis, the process analysis and the user analysis. The goal of this research was to gain a better understanding on the problem, the context, the user and its needs. The outcomes of the analysis were the list of requirements, the design and the interaction visions. The most important requirements stated that the product should be easy to handle, allow increasing and decreasing the guide wire loop, and facilitate locking the loop in any position. Based on the research outcomes, the ideation and conceptualization processes were conducted. Several ideation methods were used, such as: brainstorming sessions, morphological charts and shape explorations. Starting from the developed ideas and from the program of requirements, three concepts were developed. In order to select the most suitable concept, a selection method was used. Three most important criteria were used to evaluate the three concepts and to select the one that would be detailed in embodiment. Based on the cost, ergonomics and look & feel, the second concept was selected. The next phase of the design process was the embodiment. In this phase, the concept was separated in several parts, which were optimized and detailed: the casing, the locking mechanism, the loop mechanism, the locking mechanism, the controllers and the stock parts. The parts were developed and then assembled together in the final product. Several models and prototypes were built during the embodiment phase, in order to test various functional principles. Finally, a user testing session was organized. Prototyping First prototype The first prototype was 3D printed in the Faculty of Industrial Design Engineering, TU Delft. This prototype was built after all the parts were optimized and detailed, and had the goal to test the functioning principles of the product. The prototype did not have the same look and feel as the final product was intended. However, the other aspects of the prototype were very close to the actual product. The designed parts were 3D printed based on the Solidworks models, and the stock parts were ordered from Qosina. The parts were assembled together and the loop catheter was included. The working principles of the product were tested and validated.