Print Email Facebook Twitter Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis Title Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis Author Meskers, C.G.M. Schouten, A.C. Rich, M.M.L. De Groot, J.H. Schuurmans, J. Arendzen, J.H. Faculty Applied Sciences Department Biomechanical Engineering Date 2009-11-26 Abstract The long latency M2 electromyographic response of a suddenly stretched active muscle is stretch duration dependent of which the nature is unclear. We investigated the inXuence of the group II aVerent blocker tizanidine on M2 response characteristics of the m. Xexor carpi radialis (FCR). M2 response magnitude and eliciting probability in a group of subjects receiving 4 mg of tizanidine orally were found to be signiWcantly depressed by tizanidine while tizanidine did not aVect the signiWcant linear relation of the M2 response to stretch duration. The eVect of tizanidine on the M2 response of FCR is supportive of a group II aVerent contribution to a compound response of which the stretch duration dependency originates from a diVerent mechanism, e.g., rebound Ia Wring. Subject M2 responseII aVerentStretch reXexTizanidine To reference this document use: http://resolver.tudelft.nl/uuid:def9e955-cda6-4dd2-85ea-54112c53379f DOI https://doi.org/10.1007/s00221-009-2085-x Publisher Springer ISSN 1432-1106 Source Experimental brain research, 201 (4), 2010 Part of collection Institutional Repository Document type journal article Rights (c) 2009 The Author(s). This article is published with open access at Springerlink.com Files PDF meskers.pdf 428.09 KB Close viewer /islandora/object/uuid:def9e955-cda6-4dd2-85ea-54112c53379f/datastream/OBJ/view