Print Email Facebook Twitter Novel microelectrode arrays for in-vitro analysis of neural activity Title Novel microelectrode arrays for in-vitro analysis of neural activity Author Vyza, Yashwanth (TU Delft Electrical Engineering, Mathematics and Computer Science) Contributor Valente, V. (mentor) Renz, Aline (mentor) Weaver, Sean (mentor) Voros, Janos (mentor) Serdijn, W.A. (graduation committee) Dekker, Ronald (graduation committee) Degree granting institution Delft University of Technology Date 2019-08-22 Abstract Microelectrode arrays (MEAs) are extensively used for measuring neural activity in-vitro given their ability to monitor several neurons simultaneously unlike techniques such as patch clamp. However, MEAs still have limitations in acquiring high spatial resolution data due to limited number of channels that can be parallelly scanned, the need for bulky anti-aliasing filters, and limitations in signal-to-noise ratio (SNR) arising from thermal noise. Commercially available MEAs rely on resistive or self-capacitive sensing scheme, but this research proposes a new approach to increase the number of sensing locations while reducing the channels and to increase SNR. Fundamental design aspects of a MEA such as the shape and size of electrodes are revisited. By employing traditional lithographic fabrication techniques, these arrays with various geometries are fabricated and characterized. Neural cultures are seeded on these novel MEAs to record neural activity in the electrical domain and concurrently Ca+2 Imaging is performed to correlate and verify the activity of a neuron. Subject Microelectrode arraysNeural interfaceIn-vitro analysis To reference this document use: http://resolver.tudelft.nl/uuid:df36a2dd-caa3-455b-84a7-77f99511d4b6 Embargo date 2023-07-01 Part of collection Student theses Document type master thesis Rights © 2019 Yashwanth Vyza Files PDF Thesisreport_YSR.VYZA_4740378.pdf 138.12 MB Close viewer /islandora/object/uuid:df36a2dd-caa3-455b-84a7-77f99511d4b6/datastream/OBJ/view