Print Email Facebook Twitter Suitability of Biodegradable Polymersomes as Radionuclide Carriers Title Suitability of Biodegradable Polymersomes as Radionuclide Carriers Author Sanders, T.J. Contributor Denkova, A.G. (mentor) Faculty Applied Sciences Department Radiation Science and Technology Programme Radiation and Isotopes for Health Date 2014-06-14 Abstract Suitability of biodegradable polymersomes functioning as radionuclide carriers is assessed. Biodegradable polymersomes employed in this research were composed of either diblock copolymers, poly(caprolactone)-poly(ethylene oxide)(PCL-PEO) or poly(lactic acid)-poly(ethyleneoxide)(PLA-PEO). The initial aim was to investigate and optimize various methods for the formation and size reduction of these polymer vesicles. Significantly improved formation of PCL-PEO based polymersomes was observed at elevated temperatures. For assessing their fictionalization as radionuclide carriers, the polymersomes were actively loaded with the radionuclide Indium-111. For PCL-PEO and PLA-PEO based polymersomes radionuclide loading efficiencies of up to 82% and 71% respectively were established. Subject polymersomeradionuclideradiotherapybiodegradable To reference this document use: http://resolver.tudelft.nl/uuid:e085327f-947d-46f9-b1f3-a1b438e14f3f Part of collection Student theses Document type master thesis Rights (c) 2014 Sanders, T.J. Files PDF Master_Thesis_TJ_SANDERS_d.pdf 3.73 MB Close viewer /islandora/object/uuid:e085327f-947d-46f9-b1f3-a1b438e14f3f/datastream/OBJ/view