Print Email Facebook Twitter A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding Title A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding Author Koppenol, D.C. (TU Delft Numerical Analysis) Vermolen, F.J. (TU Delft Numerical Analysis) Niessen, Frank B. (Red Cross Hospital) van Zuijlen, Paul P.M. (Amsterdam UMC; Red Cross Hospital) Vuik, Cornelis (TU Delft Numerical Analysis) Date 2016 Abstract A continuum hypothesis-based model is presented for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding. Solely the dermal layer of the skin is modeled explicitly and it is modeled as a heterogeneous, isotropic and compressible neo-Hookean solid. With respect to the constituents of the dermal layer, the following components are selected as primary model components: fibroblasts, myofibroblasts, a generic signaling molecule and collagen molecules. A good match with respect to the evolution of the thickness of the dermal layer of scars between the outcomes of simulations and clinical measurements on hypertrophic scars at different time points after injury in human subjects is demonstrated. Interestingly, the comparison between the outcomes of the simulations and the clinical measurements demonstrates that a relatively high apoptosis rate of myofibroblasts results in scar tissue that behaves more like normal scar tissue with respect to the evolution of the thickness of the tissue over time, while a relatively low apoptosis rate results in scar tissue that behaves like hypertrophic scar tissue with respect to the evolution of the thickness of the tissue over time. Our ultimate goal is to construct models with which the properties of newly generated tissues that form during wound healing can be predicted with a high degree of certainty. The development of the presented model is considered by us as a step toward their construction. Subject Dermal wound healingHypertrophic scar tissueFibroblastsCompressible neo-Hookean solidModelingBiomechanicsMoving boundaryMoving-grid finite-element methodFlux-corrected transport (FCT) limiter To reference this document use: http://resolver.tudelft.nl/uuid:e3fd9117-63b4-4b85-bd7c-a09fee7fe38e DOI https://doi.org/10.1007/s10237-016-0799-9 ISSN 1617-7959 Source Biomechanics and Modeling in Mechanobiology (online), 16 (1), 15-32 Part of collection Institutional Repository Document type journal article Rights © 2016 D.C. Koppenol, F.J. Vermolen, Frank B. Niessen, Paul P.M. van Zuijlen, Cornelis Vuik Files PDF 11146805.pdf 2.08 MB Close viewer /islandora/object/uuid:e3fd9117-63b4-4b85-bd7c-a09fee7fe38e/datastream/OBJ/view