Title
A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy
Author
Choi, Yeon Sik (Northwestern University; Sungkyunkwan University)
Jeong, Hyoyoung (Northwestern University)
Yin, Rose T. (The George Washington University)
Avila, Raudel (Northwestern University)
Pfenniger, Anna (Northwestern University Feinberg School of Medicine)
Yoo, Jaeyoung (Northwestern University)
Lee, Jong Yoon (Northwestern University; Sibel Health, Niles)
Tzavelis, Andreas (Northwestern University)
Rwei, A.Y. (TU Delft ChemE/Product and Process Engineering) 
Date
2022
Abstract
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
To reference this document use:
http://resolver.tudelft.nl/uuid:e6f48251-0247-47b2-b3ae-a17fab62c390
DOI
https://doi.org/10.1126/science.abm1703
Embargo date
2022-11-27
ISSN
0036-8075
Source
Science, 376 (6596), 1006-1012
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2022 Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, A.Y. Rwei, More Authors