Print Email Facebook Twitter Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions Title Collective diffusion coefficient of proteins with hydrodynamic, electrostatic, and adhesive interactions Author Prinsen, P. Odijk, T. Faculty Applied Sciences Date 2007-09-20 Abstract A theory is presented for ?C, the coefficient of the first-order correction in the density of the collective diffusion coefficient, for protein spheres interacting by electrostatic and adhesive forces. An extensive numerical analysis of the Stokesian hydrodynamics of two moving spheres is given so as to gauge the precise impact of lubrication forces. An effective stickiness is introduced and a simple formula for ?C in terms of this variable is put forward. A precise though more elaborate approximation for ?C is also developed. These and numerically exact expressions for ?C are compared with experimental data on lysozyme at pH 4.5 and a range of ionic strengths between 0.05M and 2M. Subject adhesiondiffusionelectrostaticsenzymeshydrodynamics To reference this document use: http://resolver.tudelft.nl/uuid:ef37a79f-bfd2-453c-a91b-b641120aa284 DOI https://doi.org/10.1063/1.2771160 Publisher American Institute of Physics ISSN 0021-9606 Source http://link.aip.org/link/JCPSA6/v127/i11/p115102/s1 Source Journal of Chemical Physics, 127 (11), 2007 Part of collection Institutional Repository Document type journal article Rights (c) 2007 Prinsen, P.; Odijk, T.; American Institute of Physics Files PDF 2007-1.pdf 169.01 KB Close viewer /islandora/object/uuid:ef37a79f-bfd2-453c-a91b-b641120aa284/datastream/OBJ/view