Print Email Facebook Twitter SPECT/CT Imaging of Pluronic Nanocarriers with Varying Poly(ethylene oxide) Block Length and Aggregation State Title SPECT/CT Imaging of Pluronic Nanocarriers with Varying Poly(ethylene oxide) Block Length and Aggregation State Author Arranja, Alexandra (External organisation) Ivashchenko, O. (TU Delft RST/Biomedical Imaging; MILabs B.V.; University Medical Center Utrecht) Denkova, A.G. (TU Delft RST/Applied Radiation & Isotopes) Morawska, K.M. (Universiteit Gent) Van Vlierberghe, Sandra (Universiteit Gent) Dubruel, Peter (Universiteit Gent) Waton, Gilles (Institut Charles Sadron) Beekman, F.J. (TU Delft RST/Biomedical Imaging; MILabs B.V.; University Medical Center Utrecht) Schosseler, François (Institut Charles Sadron) Mendes, E. (TU Delft ChemE/Advanced Soft Matter) Date 2016-03-07 Abstract Optimal biodistribution and prolonged circulation of nanocarriers improve diagnostic and therapeutic effects of enhanced permeability and retention-based nanomedicines. Despite extensive use of Pluronics in polymer-based pharmaceuticals, the influence of different poly(ethylene oxide) (PEO) block length and aggregation state on the biodistribution of the carriers is rather unexplored. In this work, we studied these effects by evaluating the biodistribution of Pluronic unimers and cross-linked micelles with different PEO block size. In vivo biodistribution of 111In-radiolabeled Pluronic nanocarriers was investigated in healthy mice using single photon emission computed tomography. All carriers show fast uptake in the organs from the reticuloendothelial system followed by a steady elimination through the hepatobiliary tract and renal filtration. The PEO block length affects the initial renal clearance of the compounds and the overall liver uptake. The aggregation state influences the long-term accumulation of the nanocarriers in the liver. We showed that the circulation time and elimination pathways can be tuned by varying the physicochemical properties of Pluronic copolymers. Our results can be beneficial for the design of future Pluronic-based nanomedicines. Subject micellesPluronicSPECTunimers To reference this document use: http://resolver.tudelft.nl/uuid:f8d8e9c2-0e84-403c-b880-1ad8b90e4177 DOI https://doi.org/10.1021/acs.molpharmaceut.5b00958 ISSN 1543-8384 Source Molecular Pharmaceutics, 13 (3), 1158-1165 Bibliographical note Version before revisions, but the revisions were minor. Part of collection Institutional Repository Document type journal article Rights © 2016 Alexandra Arranja, O. Ivashchenko, A.G. Denkova, K.M. Morawska, Sandra Van Vlierberghe, Peter Dubruel, Gilles Waton, F.J. Beekman, François Schosseler, E. Mendes Files PDF SPECT_CT_imaging_pluronic ... rriers.pdf 1.89 MB Close viewer /islandora/object/uuid:f8d8e9c2-0e84-403c-b880-1ad8b90e4177/datastream/OBJ/view